The effect of Avemar on the Immune system complex.
 
 

The effect of Avemar is complex.
This diagram highlights 4 possible actions of Avemar on the immune system.



1. Apoptosis of cancer cells


Apoptosis of cancer cells is increased significantly by Avemar.
Normal cells are not affected.
In tumour cells the reduction of tyrosine is a trigger for apoptosis (natural cell death)
therefore Avemar increases the death of damaged cells.

 

 

2. Increasing the synthesis  of I-CAM1 proteins

Avemar increasing significantly the synthesis of I-CAM1 proteins , there by also the cellular anti-cancer immune response.

Avemar slows the proliferation of damaged cells by altering the rate of glucose intake and the synthesis of nucleic acid ribose. Slows the production of cancer cells. Avemar decreases G6PDH and transketolase activities that are key enzymes in glucose conversion to ribose precursors. Avemar is a powerful inhibitor of nucleic acid synthesis, which likely is the underlying mechanism of its anti-proliferative tumour growth contolling potential.

Tumours are low in I-CAM1, which prevents a natural attack on the tumour. Avemar increases I-CAM1 thus allowing the cellular anti cancer immune response to function.



 

 

3. Tumour Necrosis Factorŕ Production (TNFa)

As a synergist, Avemar significantly increases the production of TNFa by macrophages activated against tumour cells.

One of the most important cytokines responsible for the destruction of cancer cells is TNFa, which is produced by the immune system. Avemar significantly increases the production of TNFa.

 

 

4. Down regulation of the MHCI molecule

Avemar significantly decreases the synthesis of molecule MHCI by the cancer cell, eliminating the masking properties of tumour cells, so they are destroyed by the natural killer cells.

Down regulation of MHC-I.
Cancer cells can mask themselves from Natural Killer (NK) cells. Many therapies claim an ability to increase NK levels but if they are unable to detect cancer cells this is of little value to the patient. Avemar unmasks the damaged cells allowing normal levels of NK cells to destroy them.

 

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