SUPPORTIVE EFFECTS OF AVEMAR® IN BREAST CANCER
Center: Clinic of Surgery, University of Szeged
Principal investigator: Prof. Dr. Ádám Balogh MD, PhD, Director of Clinic
Duration of study: 1999-2001
Number of patients: 39
Mean duration of Avemar treatment: 19.3 months
Staging of patients at baseline:
UICC staging Number of pts % I 3 7.7
II 14 35.9
III 9 23.1 IV 13 33.3
ResultsChanges in side effects of chemotherapy due to Avemar treatment Number of pts % No changes 15 38.5
Ameliorated 10 25.6
Ceased 14 35.9
Changes in body mass (meanąSD) of pts due to Avemar treatment Before Avemar treatment After Avemar treatment Difference Significancy
70.2 ą13.9 75.4 ą 14.6 +5.1 ą 6.1 P<0.001
Conclusions: Supportive treatment of breast cancer patients with Avemar resulted in significant amelioration/ceasing of the side effects of chemotherapy, and significant increase of body mass. EFFECTS OF LONG-TERM AVEMARŽ TREATMENT ON QUALITY OF LIFE IN BREAST CANCER
Statistical evaluation of EORTC QLQ-C30 questionnaires
Center: Clinic of Surgery, University of Szeged
Principal investigator: Prof. Dr. Ádám Balogh MD, PhD, Director of Clinic
Duration of study: 1999-2001
Number of patients: 55
Mean duration of Avemar treatment: 32.2 months
Staging of patients at baseline:
UICC staging
I 8 14.5
II 19 34.5
III 15 27.3
IV 13 23.6
Results
Quality components
Functional scales Significancy
Physical functions P<0.05
Daily activity at home .N.S
Emotional functions P<0.001
Cognitive functions N.S.
Social functions N.S.
Global state of health P<0.01
Symptomatic scales
Fatigue P<0.01
Nausea, vomiting P<0.01
Pain N.S.
Dyspnoe N.S.
Insomnia P<0,01
Asitia N.S.
Constipation P<0,01
Diarrhoea N.S.
Financial problems N.S.
Conclusions: Supportive Avemar treament of breast cancer patients resulted in significant improvements of several components of quality of life. These effects were manifested after three months of Avemar treatment and remained stabilized thorought the entire period of the study.
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